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Welcome to the UAB Foundation

Stanford UAB study


Opportunity to speak with Stanford Biodesign!

Calling all UAB patients: Two teams at Stanford Biodesign (biodesign.stanford.edu) are working on new treatments for underactive bladder and they would like to speak with you to better understand your needs. Come be a part of helping the thousands of other individuals with this condition.

Stanford’s Biodesign program is dedicated to creating and implementing innovative medical technologies. Patients are at the heart of this innovation – it is their need for better solutions that is driving the initiative forward. If you or someone you know is diagnosed with underactive bladder and is interested in helping advance underactive bladder research please send an email to This e-mail address is being protected from spambots. You need JavaScript enabled to view it .

What is Underactive Bladder Syndrome?


The Underactive Bladder is a symptom complex suggestive of detrusor underactivity and is usually characterized by prolonged urination time with or without a sensation of incomplete bladder emptying, usually with hesitancy, reduced sensation on filling, and a slow stream.

Underactive Bladder Syndrome is a chronic, complex and debilitating disease which affects the urinary bladder with serious consequences. Patients with an underactive bladder can hold unusually large amounts of urine but has a diminished sense of when the bladder is full and is not able to contract the muscles sufficiently and as forcefully as it should, resulting in incomplete bladder emptying.

The symptoms and severity of underactive bladder vary from one person to another and the course of the disease is often unpredictable.

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Risk Factors for underactive bladder


Scientists are working diligently to understand what biological factors contribute to underactive bladder pathogenesis. The most common risk factors associated with this syndrome are:

Nerve Damage

Damage to the peripheral nerves of the bladder by congenital, inflammatory, neoplastic or traumatic lesions may cause the sensation of bladder filling to be absent or reduced, and large volumes of urine may accumulate, which causes difficulty in emptying the bladder.


High blood sugar causes damage to peripheral nerves supplying bladder wall. Normal urination relies on the synergy between bladder contractions and bladder neck opening. When this is interrupted, such as diabetic patients, the result is incomplete bladder emptying with significant residual volumes.

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