Welcome to the UAB Foundation
Underactive Bladder Syndrome is defined as urinary symptoms including hesitancy, straining and incomplete bladder emptying in the absence of anatomic obstruction.
Underactive Bladder Syndrome is a chronic, complex and debilitating disease which affects the urinary bladder with serious consequences. Patients with an underactive bladder can hold unusually large amounts of urine but has a diminished sense of when the bladder is full and is not able to contract the muscles sufficiently and as forcefully as it should, resulting in incomplete bladder emptying.
The symptoms and severity of underactive bladder vary from one person to another and the course of the disease is often unpredictable.
Scientists are working diligently to understand what biological factors contribute to underactive bladder pathogenesis. The most common risk factors associated with this syndrome are:
Damage to the peripheral nerves of the bladder by congenital, inflammatory, neoplastic or traumatic lesions may cause the sensation of bladder filling to be absent or reduced, and large volumes of urine may accumulate, which causes difficulty in emptying the bladder.
High blood sugar causes damage to peripheral nerves supplying bladder wall. Normal urination relies on the synergy between bladder contractions and bladder neck opening. When this is interrupted, such as diabetic patients, the result is incomplete bladder emptying with significant residual volumes.